Patents
Granted Patents
Surface-modified inorganic substrate and method for preparation thereof
Abstract: The present invention relates to the field of surface modification of metal hydroxide and/or oxide surfaces of inorganic substrates. In particular, the invention provides a method for the modification of metal hydroxide and/or metal oxide surfaces of an inorganic substrate with an organometallic reagent for obtaining an organic functionalized substrate suitable for filtration processes. The present method involves the direct covalent binding of one or more different organic functional moieties to a surface of said substrate by application of organometallic chemistry. The invention further relates to surface-modified inorganic substrates and to various industrial uses of surface-modified substrates according to the invention.
Inventors: Anita Buekenhoudt, Kenny Wyns, Vera Meynen, Bert Maes, Pegie Cool
Process for the
catalytic directed cleavage of amide-containing compounds
Abstract: The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR') or an alcohol (ROH) or thiol (RSH)).
Inventors: Bert Maes, Clarence Wybon, Chen Chen, Charles Beromeo Bheeter, Serguei Sergueev
Patent applications reaching the PCT or national phase
Process for preparing
a polycarbonate by metal catalyzed cross coupling
The present invention relates to a process for preparing a polycarbonate using metal-catalyzed cross-coupling, including the reaction of an iodinated diaryl carbonate with a structure of formula (I) and a terminal alkyne with a structure of formula (IIa) or a terminal alkene with a structure of formula (IIb). Furthermore, the invention relates to a polycarbonate comprising a repeating unit with a structure of formula (IIIa) or (IIIb).
Inventors: Bernd Garska, Jan Heijl, Pieter Mampuys, Bert Maes,
Process for preparing polycarbonate by Blanc-type methylation
Abstract: The present invention relates to a process for preparing a polycarbonate using electrophilic aromatic substitution including the reaction of chlorosulfonic acid together with a specific compound of formula (2).
Inventors: Bernd Garska, Jan Heijl, Pieter Mampuys, Bert Maes,
Process for preparing a polycarbonate by Friedel-Crafts acylation
Abstract: The present invention relates to a process for preparing a polycarbonate using electrophilic aromatic substitution including the reaction of a diaryl carbonate with a structure of formula (I) and an acyl halide, preferably an acyl chloride or acyl bromide, with a structure of formula (IIa) or an anhydride with a structure of formula (IIb).
Inventors: Bernd Garska, Jan Heijl, Bert Maes, Pieter Mampuys
Process for preparing a polycarbonate by Friedel-Crafts alkylation
Abstract: The present invention relates to a process for preparing a polycarbonate using electrophilic aromatic substitution, comprising a reaction of a diaryl carbonate with a structure of formula (I) and a primary alkyl halide with a structure of formula (IIa) or (IIb).
Inventors: Bernd Garska, Jan Heijl, Pieter Mampuys, Bert Maes
Process for preparing a polycarbonate by Friedel-Crafts alkylation
Abstract: The present invention relates to a process for preparing a polycarbonate using electrophilic aromatic substitution, comprising a reaction of a diaryl carbonate with a structure of formula (I) and a dichloromethylbenzene with a structure of formula (II).
Inventors: Bernd Garska, Jan Heijl, Bert Maes, Pieter Mampuys
Method for the
deacylation and/or dealkylation of compounds
Abstract: The present invention in general relates to a method for the deacylation and/or dealkylation (both O-dealkylation as well as C-dealkylation) of compounds, more specifically of aromatic compounds. The method is characterized by contacting the compound with an acid-containing aqueous reaction mixture using high temperature and high pressure conditions. The invention also provides a method for preparing a compound suitable for further deacylation using the method of the invention.
Inventors: Bert Maes, Jeroen Bomon, Serguei Sergueev, Enguerrand Blondiaux
Process for the production of levulinic acid and derivatives thereof
Abstract: The present invention relates to the field of organic synthesis, and in particular, the present invention pertains to a process for preparing a levulinic acid or salt thereof, or levulinate.
Inventors: Bert Maes, Céderic Ver Elst, Mathias Bal
Preparation of
fluoroaromatic derivatives useful as anti-HIV compounds
Abstract: The present invention relates to the field of HIV-1 infections, and in particular provides novel compounds containing fluorine on the Central ring. The compounds according to this invention are very suitable for the prevention and/or treatment of HIV-1 infection and in particular show higher activity against NNRTI-resistant strains of HIV-1.
Inventors: Philippe Franck, Jan Heeres, Bert Maes, Serguei Sergueev, Ashok Kumar Yadav, Paulus Joannes Lewi
Recycling of organotin compounds
Abstract: A method for the synthesis of a first organic molecule, said method comprising the steps of: a) Reacting a first reactant with an organotin reactant having at least one optionally substituted organic group having from 5 to 20 carbon atoms selected from alkyl, alkenyl, alkynyl, alkoxyalkyl, alkoxy, alkylthioalkyl, carboxylates and alkylaminoalkyl groups, thereby forming a mixture of a product and a tin-containing by-product, and b) Removing most of the tin-containing by-product from said mixture in such a way as to provide a purified product comprising less than 1000 ppm of remaining tin-containing by- product, wherein said step of removing most of said tin-containing by-product is either an extraction between a first liquid and a second liquid, said second liquid being more polar than said first liquid and at least partly immiscible therewith or is a reversed phase chromatography.
Inventors: Alexandr Kuvshinov, Philippe Franck, Stefaan Depraetere, Bert Maes, Johan De Houwer, Clarence Wybon, Hans Sterckx, Serguei Sergueev